cartouche ECN WORKSHOP
-

Abstracts

Oral communications

1

2025 - Oral communication

Hyperuricemia and gout - treatment

Exploring Quality of Life Outcomes in Gout in Patients on a Treat-to-Target (TTT) Regime

Rowan Hart BMedSci (1), Amrey Krause PhD (2), Debbie Alexander BSc (1), Barbara Hauser PhD (1), Barbara Kuske PhD (1), Philip L Riches PhD (1)

2

2025 - Oral communication

OA-Genetics and EUROGOUT-Inflammation

Differential DNA methylation patterns in hyperuricemic and normouricemic individuals

Medeea Badii (1,2), Zhaoli Liu (3), Orsolya Gaal (1,2), Georgiana Cabău (1), Valentin Nica (1), Ancuta R. Straton (1), Ioana Hotea (4), Hint Consortium, Cristina Pamfil (4), Simona Rednic (4), Radu A Popp (1), Cheng-Jian Xu (6, Tania O Crişan (1,2), Leo A B Joosten (1,2)

3

2025 - Oral communication

Mechanisms of Calcification

Raman spectroscopic characterization of calcium pyrophosphate crystals in synovial fluid identifies presence of triclinic CPP only

Dr. Tom Niessink (1,2), Florina Ionete (3,4), Dr. Martijn Gerritsen (5), Pr. Dr. Ea Hang Korng (6), Pr. Dr Pascal Richette (6), Pr. Dr. Tim Welting (7), Pr. Dr. Tristan Pascart (8), Dr. Matthijs Janssen (1), Pr. Dr. Cees Otto (2), Dr. Tim L Jansen (1)

4

2025 - Oral communication

Hyperuricemia and gout - treatment

Defining colchicine in-vitro effect on MSU crystals stimulated peripheral blood mononuclear cells.

Laura M. Merlo Pich (1), Calin D. Popa (2,3), Leo A.B. Joosten 1,4), Mihai G. Netea (1,5)

5

2025 - Oral communication

Crystal-Induced Inflammation

Variation in PBMC cytokine response to crystal-related stimuli: how much can we explain?

Nicholas A Sumpter (1), Brenda Kischkel (1), Suzanne Ruijten (1), Hang-Korng Ea (2), Leo A.B. Joosten (1,3)

6

2025 - Oral communication

Crystal-Induced Inflammation

Association of Chondrocalcinosis with disease activity and drug response in Rheumatoid Arthritis: Baseline characteristics of the Swiss Rheumatoid Arthritis Outcomes cohort

Tobias Manigold (1), Nicolas Bodmer (2), Elisabeth Rosoux (4), Guillaume Fahrni (3), Deborah Markham (4), Raphael Micheroli (5), Lucas M. Bachmann (2), Jonas Brändli (6), Fabio Becce (3), Thomas Hügle (3)

7

2025 - Oral communication

Hyperuricemia and gout - treatment

Cost-effectiveness of nurse-led home monitoring of serum uric acid values for gout patients in secondary care: a modelling study

Jeffrey Van Der Ven, Msc; Marcel Flendrie, Md, Phd; Fenne Van Dijck; Maike Wientjes, Msc; Noortje Van Herwaarden, Md, Phd; Philip L Riches, Md, Phd; Bart J.f. Van Den Bemt, Prof., Phd; Lise M. Verhoef, Phd

8

2025 - Oral communication

Hyperuricemia and gout - treatment

The Young, the Metabolic and the Hypertensive. A cluster analysis of gout patients and its comorbidities.

Maria Antonia Pou, Carlen Reyes, Daniel Martinez-Laguna, Pau Satorra, Cristian Tebe, Nicola Dalbeth, Cesar Diaz-Torne

9

2025 - Oral communication

Crystal-Induced Inflammation

Identification of metabolite profiles during gout flare in a prospective gout cohort: glutamine and histidine as anti-inflammatory metabolites

Charles Leroy, Phd Student ; Nghia Pham, Md; François Brial, Phd; Brenda Kischkel, Phd; Gwénaëlle Jayat ; Elena Ishow, Phd; Christèle Combes, Phd; Leo Joosten, Phd; Augustin Latourte,md,phd; Pascale Richette, Md, Phd; Hang-Korng Ea, Md, Phd

10

2025 - Oral communication

OA-Genetics and EUROGOUT-Inflammation

IL1β promoter polymorphism rs16944 and cytokine production in hyperuricemia and gout

Maria Muntiu (1), Andreea Manuela Mirea (1), Medeea Badii (1,2), Orsolya Gaal (1,2), Georgiana Cabău (1), Valentin Nica (1), Cristina Pamfil (3), Simona Rednic (3), Tania O. Crişan (1,2), Leo A.B. Joosten (1,2)

11

2025 - Oral communication

Crystal-Induced Inflammation

Positive allosteric modulators (PAMs) of cystathionine gamma lyase (CSE) increase hydrogen sulfide (H2S) and inhibit NLRP3 activation

Driss Ehirchiou (1), Twinu Chirayath (2), Sonia Nasi (2), Veronique Chobaz (2), Rainer Riedl (3), Cindy Blatter (3), Stefan Germann (3), Alexandra Brandenberger (3), Nathalie Busso (2, Alexander So (1)

12

2025 - Oral communication

Crystal-Induced Inflammation

A Proteomic Analysis Of Subclinical Synovial Inflammation Associated With Monosodium Urate Crystal Deposition.

Mariano Andrés* (1,2), María-Luisa Peral-Garrido (3), Samanta Ortuño (1), Rocío Caño (1), Silvia Gómez-Sabater (1), Alejandra Bermúdez-García 1, Teresa Lozano (1), Miguel Perdiguero (1), Elena Caro-Martínez (4), Ruth Sánchez-Ortiga (1), Carolina Ruiz-García (5), Rubén Francés (1,2).

13

2025 - Oral communication

OA-Genetics and EUROGOUT-Inflammation

Genome-wide association study in chondrocalcinosis reveals ENPP1 as a candidate therapeutic target in calcium pyrophosphate deposition disease

Riku Takei, Ann Rosenthal, Tristan Pascart, Richard Reynolds, Tuhina Neogi, Robert Terkeltaub, Sara Tedeschi, Tony Merriman

14

2025 - Oral communication

Hyperuricemia and gout - treatment

Safety and Efficacy of Monthly Dosing of Pegloticase (Every 4 Weeks) With Methotrexate Co-administration in Patients with Uncontrolled Gout: Phase 4 FORWARD Open-label Trial

Orrin Troum (1), John K. Botson (2), Fang Fang (3), Katie Obermeyer (3), Afroz S. Mohammad (3), Supra Verma (3), Brian Lamoreaux 3)

15

2025 - Oral communication

Mechanisms of Calcification

Characterization of the zone of calcified cartilage and the chondrocyte phenotype in osteoarthritis patients

Andrea Schwab (1,2), Judith Veldman (1), Nicole Kops (1), Xander den Dekker (1), Kayleigh Hiscock (1), Wilfred van Ijcken (1), Merve Sinram (1, Brigitta Stolze (1), Heiko Richter (1), Jessica Bertrand (2), Eric Farrell (1), Gerjo JVM van Osch (1)

16

2025 - Oral communication

Crystal-Induced Inflammation

Hyperuricemia and inflammation in chronic inflammatory arthritis: A post-hoc analysis of the CARMA project

Antonio Avilés (1,2) , Zulema Plaza (3) , Fernando Sánchez-Alonso (3) , Santos Castañeda (4), Benjamín Fernández (5) , César Díaz (6) , Pilar Font (7), Olga Martínez (8) , Emilio Giner (9), José Miguel Senabre (10) , Amalia Rueda (11) , Ana Pérez (12) , Gines Sanchez (13 , Carlos González (14), Javier García (15) , Javier Llorca (16), Miguel Ángel González-Gay (16,17) , Mariano Andrés (1,2,18).

17

2025 - Oral communication

Crystal-Induced Inflammation

Intracellular fates of monosodium urate and calcium pyrophosphate crystals in macrophages and their dissolution.

Charles Leroy, Phd Student ; Nghia Pham, Md; François Brial, Phd; Brenda Kischkel, Phd; Gwénaëlle Jayat ; Elena Ishow, Phd; Christèle Combes, Phd; Leo Joosten, Phd; Augustin Latourte,md,phd; Pascale Richette, Md, Phd; Hang-Korng Ea, Md, Phd

18

2025 - Oral communication

Mechanisms of Calcification

Identification of calcification types of meniscus samples and correlation with degradation severity in osteoarthritis patients

Hilke Lemke, Sina Stuecker, Andrea Schwab, Agnieszka Halm-Pozniak, Jannik Jahn, Christoph H Lohmann, Jessica Bertrand

19

2025 - Oral communication

Crystal-Induced Inflammation

Urate transport mediated by SLC23A proteins that are known as vitamin C transporters

Yu Toyoda (1,2), Hiroshi Miyata (2), Hirotaka Matsuo (1), Tappei Takada (2)

Posters

20

2025 - Poster

Hyperuricemia and gout - treatment

Comorbidity burden and health resource utilization in controlled vs. uncontrolled gout: A retrospective claims-based analysis

Richard Lai (1), Suneet Grewal (2), Kaiding Zhu (3), Stephani Gray (3), Andrea Meyers (3), Brian Lamoreaux (3)

21

2025 - Poster

Hyperuricemia and gout - treatment

Colchicine efficacy and safety in crystal-induced arthritis flare in patients with severe chronic kidney disease

Lecrosnier Aude (1), Barat Eric Pharm. D (2), Ottaviani Sébastien Md (3), Rat Anne-Christine Md, Phd (4), Grosjean Julien Phd (5,6), Weber Anne-Joëlle Md (7), Guerrot Dominique Md, Phd (8), Lequerré Thierry Md, Phd(1), Vittecoq Olivier Md, Phd (1), Gérard Baptiste Md (1,9*)

22

2025 - Poster

Hyperuricemia and gout - treatment

Learning from GoutSMART: predicting time to cessation of gout flares

Rowan Hart BMedSci (1), Amrey Krause PhD (2), Debbie Alexander BSc (1), Barbara Hauser PhD (1), Barbara Kuske PhD (1), Philip L Riches PhD (1)

23

2025 - Poster

Crystal-Induced Inflammation

Serum metabolomics reveals dyslipidaemia in gout and hyperuricemia: exploring inflammatory links through integrative multi-omics

Georgiana Cabău (1), Marko Barovic (2), HINT-consortium, Triantafyllos Chavakis (2), Tania O. Crișan (1), and Leo Joosten (1,3)

24

2025 - Poster

Hyperuricemia and gout - treatment

Gout characteristics, comorbidities and management in a long primary care database from Catalonia: the GotAP study.

Maria Antonia Pou, Carlen Reyes, Daniel Martinez-Laguna, Pau Satorra, Cristian Tebe, Nicola Dalbeth, Cesar Diaz-Torne

25

2025 - Poster

Hyperuricemia and gout - treatment

Identification of non-coding RNAs controlling gout-relevant genes

Nils Asmann (1), Nicholas A. Sumpter (1), Brenda Kischkel (1), Ezio T. Fok (2,3), Mumin Ozturk (2,3), Riku Takei (4), Megan P. Leask (6), Musa M. Mhlanga (2,3), Tony R. Merriman (4,5), Leo A. B. Joosten (1,7)

26

2025 - Poster

OA-Genetics and EUROGOUT-Inflammation

Telomere Length in Gout and Hyperuricemia: Analysis of Variability and Association with Mononuclear Cell Cytokine Production

Orsolya I. Gaal (1,2), Georgiana Cabau (1), Medeea Badii (1,2), Ancuta R. Straton (1), Nica Valentin (1), Maria Muntiu (1), HINT Consortium, Cristina Pamfil (3), Leo A.B. Joosten (1,2), Tania O. Crisan (1,2)

27

2025 - Poster

OA-Genetics and EUROGOUT-Inflammation

Transmembrane proteins TMEM171 and TMEM174: Two novel physiological regulators of urate homeostasis

Asim K. Mandal (1), Megan P. Leask (3,4), Hyon K. Choi (5), Julia Horsfield, Tony R. Merriman (3,6), David B. Mount (1,2)

28

2025 - Poster

Crystal-Induced Inflammation

Interleukin-40 in hyperuricemia and gout

Blanka Stiburkova (1,2), Jana Mašínová, Andrés Cerezo L( 1), Alquicer G (1), Navrátilová A (1), Pavlíková M, Šenolt L (1)