cartouche ECN WORKSHOP
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Abstracts

Oral communications

1

2025 - Oral communication

Crystal-Induced Inflammation

Variation in PBMC cytokine response to crystal-related stimuli: how much can we explain?

Nicholas A Sumpter (1), Brenda Kischkel (1), Suzanne Ruijten (1), Hang-Korng Ea (2), Leo A.B. Joosten (1,3)

2

2025 - Oral communication

Crystal-Induced Inflammation

Association of Chondrocalcinosis with disease activity and drug response in Rheumatoid Arthritis: Baseline characteristics of the Swiss Rheumatoid Arthritis Outcomes cohort

Tobias Manigold (1), Nicolas Bodmer (2), Elisabeth Rosoux (4), Guillaume Fahrni (3), Deborah Markham (4), Raphael Micheroli (5), Lucas M. Bachmann (2), Jonas Brändli (6), Fabio Becce (3), Thomas Hügle (3)

3

2025 - Oral communication

Crystal-Induced Inflammation

Identification of metabolite profiles during gout flare in a prospective gout cohort: glutamine and histidine as anti-inflammatory metabolites

Charles Leroy, Phd Student ; Nghia Pham, Md; François Brial, Phd; Brenda Kischkel, Phd; Gwénaëlle Jayat ; Elena Ishow, Phd; Christèle Combes, Phd; Leo Joosten, Phd; Augustin Latourte,md,phd; Pascale Richette, Md, Phd; Hang-Korng Ea, Md, Phd

4

2025 - Oral communication

Crystal-Induced Inflammation

Positive allosteric modulators (PAMs) of cystathionine gamma lyase (CSE) increase hydrogen sulfide (H2S) and inhibit NLRP3 activation

Driss Ehirchiou (1), Twinu Chirayath (2), Sonia Nasi (2), Veronique Chobaz (2), Rainer Riedl (3), Cindy Blatter (3), Stefan Germann (3), Alexandra Brandenberger (3), Nathalie Busso (2, Alexander So (1)

5

2025 - Oral communication

Crystal-Induced Inflammation

A Proteomic Analysis Of Subclinical Synovial Inflammation Associated With Monosodium Urate Crystal Deposition.

Mariano Andrés* (1,2), María-Luisa Peral-Garrido (3), Samanta Ortuño (1), Rocío Caño (1), Silvia Gómez-Sabater (1), Alejandra Bermúdez-García 1, Teresa Lozano (1), Miguel Perdiguero (1), Elena Caro-Martínez (4), Ruth Sánchez-Ortiga (1), Carolina Ruiz-García (5), Rubén Francés (1,2).

6

2025 - Oral communication

Crystal-Induced Inflammation

Hyperuricemia and inflammation in chronic inflammatory arthritis: A post-hoc analysis of the CARMA project

Antonio Avilés (1,2) , Zulema Plaza (3) , Fernando Sánchez-Alonso (3) , Santos Castañeda (4), Benjamín Fernández (5) , César Díaz (6) , Pilar Font (7), Olga Martínez (8) , Emilio Giner (9), José Miguel Senabre (10) , Amalia Rueda (11) , Ana Pérez (12) , Gines Sanchez (13 , Carlos González (14), Javier García (15) , Javier Llorca (16), Miguel Ángel González-Gay (16,17) , Mariano Andrés (1,2,18).

7

2025 - Oral communication

Crystal-Induced Inflammation

Intracellular fates of monosodium urate and calcium pyrophosphate crystals in macrophages and their dissolution.

Charles Leroy, Phd Student ; Nghia Pham, Md; François Brial, Phd; Brenda Kischkel, Phd; Gwénaëlle Jayat ; Elena Ishow, Phd; Christèle Combes, Phd; Leo Joosten, Phd; Augustin Latourte,md,phd; Pascale Richette, Md, Phd; Hang-Korng Ea, Md, Phd

8

2025 - Oral communication

Crystal-Induced Inflammation

Urate transport mediated by SLC23A proteins that are known as vitamin C transporters

Yu Toyoda (1,2), Hiroshi Miyata (2), Hirotaka Matsuo (1), Tappei Takada (2)

9

2024 - Oral communication

Crystal-Induced Inflammation

Ionic Profile of Synovial Fluids in Gout, Calcium Pyrophosphate Crystal Deposition Disease and Osteoarthritis

Mete Kayatekin (1), Dione Saurat1, Isabelle Rubera (1), Charles Leroy (2), Pascal Richette (2,3), Hang Korng Ea (2,3), Christophe Duranton1

10

2024 - Oral communication

Crystal-Induced Inflammation

Differences in the inflammatory proteome of gout patients during flare, inter-critical and T2T conditions reveals new disease biomarkers

Brenda Kischkel (1), Twinu Wilson Chirayath (2), Tim L. Jansen (3), Mylène Zarka (2), Tania Criçan (4), Mihai G Netea(1), Pascal Richette (2), Leo A. B. Joosten(1,4) , Hang Korng Ea (2)

11

2024 - Oral communication

Crystal-Induced Inflammation

Elucidating the pathogenicity of calciprotein particles in osteoarthritis

R.H.M.J. Stassen (1), G.G.H van den Akker (1), M.M.C Caron (1), T.J.M. Welting 1,2)

13

2024 - Oral communication

Crystal-Induced Inflammation

Intermittent fasting and spermidine reduce inflammation induced by monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystals

Nghia Pham (1), Flora Finet (1), Twinu Wilson Chirayath (1), Florence Castelli (2), François Fenaille (2), François Brial (1), Augustin Latourte (1), Frédéric Lioté (1), Pascal Richette (1), Thomas Bardin (1), Hang Korng Ea (1)

15

2022 - Oral communication

Crystal-Induced Inflammation

Source of hyperuricemia drives significantly divergent transcriptional alterations in the kidney

Victoria L Halperin Kuhns, Allison C Lane-Harris, Owen M Woodward

Posters

16

2025 - Poster

Crystal-Induced Inflammation

Serum metabolomics reveals dyslipidaemia in gout and hyperuricemia: exploring inflammatory links through integrative multi-omics

Georgiana Cabău (1), Marko Barovic (2), HINT-consortium, Triantafyllos Chavakis (2), Tania O. Crișan (1), and Leo Joosten (1,3)

17

2025 - Poster

Crystal-Induced Inflammation

Interleukin-40 in hyperuricemia and gout

Blanka Stiburkova (1,2), Jana Mašínová, Andrés Cerezo L( 1), Alquicer G (1), Navrátilová A (1), Pavlíková M, Šenolt L (1)

18

2024 - Poster

Crystal-Induced Inflammation

Integrative analysis reveals the multilateral inflammatory mechanisms of CD14 monocytes in gout

Ahmed Alaswad (1,2), Georgiana Cabău (4), Tania O. Crişan (3,4), Liang Zhou (1,2), Martijn Zoodsma (1,2), HINT Consortium (4), Mihai G Netea (3,5), Cheng-Jian Xu (1,2) Yang Li (1,2), Leo A. B. Joosten (3,4)