cartouche ECN WORKSHOP
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Abstracts

Oral communications

1

2025 - Oral communication

OA-Genetics and EUROGOUT-Inflammation

Differential DNA methylation patterns in hyperuricemic and normouricemic individuals

Medeea Badii (1,2), Zhaoli Liu (3), Orsolya Gaal (1,2), Georgiana Cabău (1), Valentin Nica (1), Ancuta R. Straton (1), Ioana Hotea (4), Hint Consortium, Cristina Pamfil (4), Simona Rednic (4), Radu A Popp (1), Cheng-Jian Xu (6, Tania O Crişan (1,2), Leo A B Joosten (1,2)

2

2025 - Oral communication

OA-Genetics and EUROGOUT-Inflammation

IL1β promoter polymorphism rs16944 and cytokine production in hyperuricemia and gout

Maria Muntiu (1), Andreea Manuela Mirea (1), Medeea Badii (1,2), Orsolya Gaal (1,2), Georgiana Cabău (1), Valentin Nica (1), Cristina Pamfil (3), Simona Rednic (3), Tania O. Crişan (1,2), Leo A.B. Joosten (1,2)

3

2025 - Oral communication

OA-Genetics and EUROGOUT-Inflammation

Genome-wide association study in chondrocalcinosis reveals ENPP1 as a candidate therapeutic target in calcium pyrophosphate deposition disease

Riku Takei, Ann Rosenthal, Tristan Pascart, Richard Reynolds, Tuhina Neogi, Robert Terkeltaub, Sara Tedeschi, Tony Merriman

4

2024 - Oral communication

OA-Genetics and EUROGOUT-Inflammation

Prediagnostic proteomics of gout: prospective cohort study of 48,898 men and women

Natalie McCormick, Amit Joshi, Robert Terkeltaub, Tony R. Merriman, Chio Yokose, Hyon K. Choi

6

2015 - Oral communication

OA-Genetics and EUROGOUT-Inflammation

Soluble urate primes inflammatory responses via activation of the Akt-PRAS40-mTOR pathway.

Tania O. Crișan (1), Maartje C.P. Cleophas (1), Kathrin Buffen (1), Tim L. Jansen (2), Charles Dinarello (1,3), Mihai G. Netea (1), Leo A.B. Joosten (1)

7

2015 - Oral communication

OA-Genetics and EUROGOUT-Inflammation

Inhibition of class I histone deacetylases as novel therapeutic option in gouty arthritis.

Maartje C.P. Cleophas (1), Tania O. Crişan (1), Charles A. Dinarello (1, 2), Mihai G. Netea (1), Leo A.B. Joosten (1)

8

2021 - Oral communication

OA-Genetics and EUROGOUT-Inflammation

Does excess weight affect gout risk differently among genetically predisposed individuals? Sex-specific prospective cohort findings over >26 years

Chio Yokose (1,2); Natalie Mccormick (1,2,3); Na Lu, (3,4); Amit D. Joshi, Mbbs (5); Hyon K. Choi (1,2,3,4)

9

2015 - Oral communication

OA-Genetics and EUROGOUT-Inflammation

Four different types of calcium pyrophosphate crystals differentially induced IL-1β production by THP-1 cells.

Laure Campillo-Gimenez (1), Pierre Gras (2), Christèle Combes (2), Martine Cohen-Solal (1,3), Frédéric Lioté (1,3), Hang-Korng Ea (1,3).

11

2024 - Oral communication

OA-Genetics and EUROGOUT-Inflammation

Transcriptomic analysis reveals a proinflammatory signature in Gout and Hyperuricemia

Valentin Nica (1), Medeea Badii (1,2),,Georgiana Cabău (1), Orsolya Gaal (1,2), Andreea-Manuela Mirea (1), Ioana Hotea (3, HINT Consortium, Cristina Pamfil (3), Simona Rednic (3), Radu A. Popp1,Yang Li (2,4), Tania O. Crișan (1,2), Leo A.B. Joosten (1,2)

12

2024 - Oral communication

OA-Genetics and EUROGOUT-Inflammation

Runt-related Transcription Factor (RUNX) 1 activation by Monosodium Urate Crystals influences the production of inflammatory cytokines in human monocytes.

Laura M. Merlo Pich (1), Viola Klück (1), Liesbeth van Emst(1), Ruiqi Liu(1), Martin Jaeger (1), Tania Crisan (2), Mihai G. Netea (1,3), Yang Li (1,4), Leo A.B. Joosten (1,2)

13

2021 - Oral communication

OA-Genetics and EUROGOUT-Inflammation

Translating the multi-trait regulatory landscape at SLC2A9

Megan Leask, James Boocock, Hyon Choi, Tayaza Fadason, Justin O’Sullivan, Lisa Stamp, Nicola Dalbeth, Julia Horsfield, Tony R Merriman

14

2020 - Oral communication

OA-Genetics and EUROGOUT-Inflammation

A putative role of IGF-1R in the pathogenesis of gout through transcription factor

R. Liu (1), O. Gaal (3), V. Klück (1), T. O. Crișan (3), S. Fanucchi (4), M. Mhlanga (4), L. Joosten (1, 2,3)

15

2021 - Oral communication

OA-Genetics and EUROGOUT-Inflammation

Recent findings in clinico-genetics analyses for clinically-defined gout

Hirotaka Matsuo (1), Masahiro Nakatochi (2), Akiyoshi Nakayama (1), Yusuke Kawamura (1), Yu Toyoda (1), Seiko Shimizu (1), Tappei Takada (3), Kimiyoshi Ichida (4), Nariyoshi Shinomiya (1), Yukinori Okada (5)

Posters

16

2025 - Poster

OA-Genetics and EUROGOUT-Inflammation

Telomere Length in Gout and Hyperuricemia: Analysis of Variability and Association with Mononuclear Cell Cytokine Production

Orsolya I. Gaal (1,2), Georgiana Cabau (1), Medeea Badii (1,2), Ancuta R. Straton (1), Nica Valentin (1), Maria Muntiu (1), HINT Consortium, Cristina Pamfil (3), Leo A.B. Joosten (1,2), Tania O. Crisan (1,2)

17

2025 - Poster

OA-Genetics and EUROGOUT-Inflammation

Transmembrane proteins TMEM171 and TMEM174: Two novel physiological regulators of urate homeostasis

Asim K. Mandal (1), Megan P. Leask (3,4), Hyon K. Choi (5), Julia Horsfield, Tony R. Merriman (3,6), David B. Mount (1,2)

18

2020 - Poster

OA-Genetics and EUROGOUT-Inflammation

Serum concentrations of IL-1β and IL-18 in gout patients out of flare are not connected to cardiovascular alterations

R. Gancheva (1), T. Velikova (2), T. Kundurzhiev (3), Z. Kolarov (1), A. Koundurdjiev (4)

19

2017 - Poster

OA-Genetics and EUROGOUT-Inflammation

Gout at the spine : a retrospective study with dual-energy computed tomography

E. Chotard (1), J. M. Sverzut (2) , F. Lioté (1,3), T. Bardin (1,3), H.K. Ea (1,3)