cartouche ECN WORKSHOP
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Abstracts

Oral communications

1

2024 - Oral communication

Mechanisms of Calcification

Development of a Deep Learning Model for Automated Detection of Calcium Pyrophosphate Deposition on Hand Radiographs

Elisabeth Rosoux (1), Thomas Hügle (2), Tobias Manigold (3), Guillaume Fahrni (1), Deborah Markham (4), Fabio Becce (1)

2

2024 - Oral communication

Hyperuricemia and gout - treatment

“Gout remission” after 1-year of intensive urate-lowering with pegloticase

Yael Klionsky (1), Karina D Torralba (2), Katie Obermeyer (3), Lissa Padnick-Silver (3), Brian LaMoreaux (3), Gordon Lam (4)

3

2024 - Oral communication

Crystal-Induced Inflammation

Ionic Profile of Synovial Fluids in Gout, Calcium Pyrophosphate Crystal Deposition Disease and Osteoarthritis

Mete Kayatekin (1), Dione Saurat1, Isabelle Rubera (1), Charles Leroy (2), Pascal Richette (2,3), Hang Korng Ea (2,3), Christophe Duranton1

5

2024 - Oral communication

Hyperuricemia and gout - treatment

Assessment of the inflammatory profile expressed in asymptomatic hyperuricemia with sonographic deposits, including a comparison with normouricemia and gout

Peral-Garrido, María-Luisa (1,4); Gómez-Sabater, Silvia (2,3); Caño, Rocío (2,3); Bermúdez-García, Alejandra (2,3) , Boix, Paula (4,5), Lozano, Teresa (3,6); Sánchez-Ortiga, Ruth (3,7); Perdiguero, Miguel (3,8); Caro-Martínez, Elena (9; Ruiz-García, Carolina (10); Francés, Rubén (3,4,5); Pascual, Eliseo (3,4); Andrés, Mariano (2,3,4).

6

2024 - Oral communication

OA-Genetics and EUROGOUT-Inflammation

Prediagnostic proteomics of gout: prospective cohort study of 48,898 men and women

Natalie McCormick, Amit Joshi, Robert Terkeltaub, Tony R. Merriman, Chio Yokose, Hyon K. Choi

7

2024 - Oral communication

Miscellaneous and rare diseases

A Comparative Analysis of Single-Energy CT and Dual-Energy CT in Detecting Crystal Deposits in Gout and Calcium Crystal Deposition Diseases

Mouad Khorsi (1), Jérôme Damet (1,2), Lucia Gallego Manzano (1), Pascal Monnin (1), Anaïs Viry (1), Fabio Becce (3)

11

2024 - Oral communication

Crystal-Induced Inflammation

Differences in the inflammatory proteome of gout patients during flare, inter-critical and T2T conditions reveals new disease biomarkers

Brenda Kischkel (1), Twinu Wilson Chirayath (2), Tim L. Jansen (3), Mylène Zarka (2), Tania Criçan (4), Mihai G Netea(1), Pascal Richette (2), Leo A. B. Joosten(1,4) , Hang Korng Ea (2)

12

2024 - Oral communication

Crystal-Induced Inflammation

Elucidating the pathogenicity of calciprotein particles in osteoarthritis

R.H.M.J. Stassen (1), G.G.H van den Akker (1), M.M.C Caron (1), T.J.M. Welting 1,2)

15

2024 - Oral communication

OA-Genetics and EUROGOUT-Inflammation

Transcriptomic analysis reveals a proinflammatory signature in Gout and Hyperuricemia

Valentin Nica (1), Medeea Badii (1,2),,Georgiana Cabău (1), Orsolya Gaal (1,2), Andreea-Manuela Mirea (1), Ioana Hotea (3, HINT Consortium, Cristina Pamfil (3), Simona Rednic (3), Radu A. Popp1,Yang Li (2,4), Tania O. Crișan (1,2), Leo A.B. Joosten (1,2)

16

2024 - Oral communication

Mechanisms of Calcification

Differential regulation of pyrophosphate metabolism in calcified and non-calcified cartilage and synovium of osteoarthritis patients

Sina Stücker, Franziska Koßlowski, Adrian Buchholz, Christoph H. Lohmann, Jessica Bertrand

17

2024 - Oral communication

Hyperuricemia and gout - treatment

Safety & efficacy of SEL-212 in patients with gout refractory to conventional treatment: outcomes from two randomized, double blind, placebo-controlled, multicenter phase 3 studies

Herbert S.B. Baraf (1, 2), Alan Kivitz (3), Sheldon Leung (4), Olu Folarin (4), Joanna Sobierska (5), Jacquie Christie (5), Anand Patel (6), Wesley DeHaan (4), Rehan Azeem (4), Peter Traber (4)

19

2024 - Oral communication

OA-Genetics and EUROGOUT-Inflammation

Runt-related Transcription Factor (RUNX) 1 activation by Monosodium Urate Crystals influences the production of inflammatory cytokines in human monocytes.

Laura M. Merlo Pich (1), Viola Klück (1), Liesbeth van Emst(1), Ruiqi Liu(1), Martin Jaeger (1), Tania Crisan (2), Mihai G. Netea (1,3), Yang Li (1,4), Leo A.B. Joosten (1,2)

20

2024 - Oral communication

Crystal-Induced Inflammation

Intermittent fasting and spermidine reduce inflammation induced by monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystals

Nghia Pham (1), Flora Finet (1), Twinu Wilson Chirayath (1), Florence Castelli (2), François Fenaille (2), François Brial (1), Augustin Latourte (1), Frédéric Lioté (1), Pascal Richette (1), Thomas Bardin (1), Hang Korng Ea (1)

21

2024 - Oral communication

Miscellaneous and rare diseases

Correlation of circulatory mineralization factors with alkaline phosphatase activity upon aging in mice and human

Virgil Tamatey (1,2) Martin Várhegyi (1,3) Dániel Kovács (1), Dénes Juhász (4), Anikó Ilona Nagy (4), Tamás Arányi (1), Flora Szeri (1)

Posters

23

2024 - Poster

Crystal-Induced Inflammation

Integrative analysis reveals the multilateral inflammatory mechanisms of CD14 monocytes in gout

Ahmed Alaswad (1,2), Georgiana Cabău (4), Tania O. Crişan (3,4), Liang Zhou (1,2), Martijn Zoodsma (1,2), HINT Consortium (4), Mihai G Netea (3,5), Cheng-Jian Xu (1,2) Yang Li (1,2), Leo A. B. Joosten (3,4)

24

2024 - Poster

Mechanisms of Calcification

Matrix GLAprotein deficiency in mice induces accelerated trachea cartilage calcification and reveals an unexpected mucosal calcification

Elodie Baptista (1), Lina Tabcheh (1), Juliana Marulanda Montoya (2, Chaohua Deng (1), Joseph Deering (3), Jean-Yves Jouzeau (1), Arnaud Bianchi (1), Marc D. McKee (3), Monzur Murshed (2), Hervé Kempf (1)

26

2024 - Poster

Hyperuricemia and gout - treatment

The response of ultrasound and clinical features of gout in patients managed with a treat-to-target serum urate protocol

David Bursill (1,2), Anita Lee1,2, Kim Griggs (1,2), Phoebe Hunter (1,2), Emma Hocking (1,2), Leah McWilliams (1), Vidya Limaye (1,2), Susanna Proudman (1,2)

27

2024 - Poster

Mechanisms of Calcification

The nomenclature of calcium pyrophosphate deposition (CPPD) disease – results of a systematic literature review for the Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN) CPPD Nomenclature Project

Charlotte Jauffret (1), Silvia Sirotti (2), Edoardo Cipolletta (3), Daniele Cirillo (4), Luca Ingrao (4), Alessandro Lucia (4), Enrico Cumbo (4), Antonella Adinolfi (6), Emilio Filippucci (3), Tristan Pascart (1), Sara K. Tedeschi (7), Robert Terkeltaub (8), Nicola Dalbeth (9), Georgios Filippou (2)

28

2024 - Poster

Hyperuricemia and gout - treatment

Urate solubility in peripheral joints: Why 6.8?

Nicholas A Sumpter (1,2), Riku Takei (1), Mariana Urquiaga (1), Angelo Gaffo (1), Tony R. Merriman (1,3)

29

2024 - Poster

Hyperuricemia and gout - treatment

A Lower Frequency of ST-Elevation Myocardial Infarction in Patients with Gout

Panagiota Drivelegka, Lennart Jacobsson, Tatiana Zverkova-Sandström, Mats Dehlin

30

2024 - Poster

Hyperuricemia and gout - treatment

"Gout was the boss": a qualitative interview study of impact of gout in work.

Cesar Diaz-Torne, Maria A. Pou, Chiara Gasteiger, Anne Horne, Nicola Dalbeth

31

2024 - Poster

Mechanisms of Calcification

Developing a Pharmacological Trial in CPPD: towards the conquer of Ithaca!

Georgios Filippou (1,2), Silvia Sirotti (1), Carlo Scirè (3), Lene Terslev (4)

33

2024 - Poster

Hyperuricemia and gout - treatment

Rasburicase and methotrexate co-therapy in a case of difficult-to-treat gout

MF Pino-Zambrano, P Cardoso-Penafiel, CM Gomez-Gonzalez, E. Calvo-Aranda

34

2024 - Poster

Mechanisms of Calcification

Improved Diagnostic Performance in Detection and Characterization of Crystals Related to Arthropathies with Photon-Counting-Detector Computed Tomography

Florian A. Huber (1), David Rotzinger (2), Matthias Zadory (3), Felix C. Müller (4), Anna Døssing (5), Veronique Schuppli (1), Lukas Moser (1), John M. Froehlich (3), Hatem Alkadhi (1), Fabio Becce(2)

35

2024 - Poster

Mechanisms of Calcification

The clinical phenotypes of calcium pyrophosphate deposition disease: data from the international cohort for the ACR/EULAR classification criteria

Tristan Pascart, Augustin Latourte, Sara K Tedeschi, Nicola Dalbeth, Tuhina Neogi, Robert Terkeltaub, Hyon K Choi, Abhishek Abhishek, on behalf of the ACR/EULAR CPPD classification criteria working group.

37

2024 - Poster

Mechanisms of Calcification

Characterization of menisci, ligaments and synovial membranes in patients with osteoarthritis and calcium pyrophosphate deposition (CPPD) by histology and Raman spectroscopy

Silvia Sirotti (1), Paola Maroni (2), Giovanni Lombardi (2,3), Tom Niessink (4), Matthijs Janssen (4), Cees Otto (5), Tim L Jansen (4), Giuseppe Peretti (6), Georgios Filippou (1,7)

39

2024 - Poster

Hyperuricemia and gout - treatment

Urinary oxypurinol as adherence to allopurinol compliance

Blanka Stiburkova (1,2), Lenka Hasikova (1), Josef Bartl (2)

42

2024 - Poster

Mechanisms of Calcification

ENPP1 deficiency is associated with structural and functional impairment of the retina

Frank Rutsch (1), Yvonne Nitschke (1), Joseph Deering (2), Dominique Bazin (3), Christoph R. Clemens (4), Uwe Hansen (5), Nicole Eter (4), Marc D. McKee (2,6), Peter Heiduschka (4)