cartouche ECN WORKSHOP
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Abstracts

Oral communications

1

2024 - Oral communication

OA-Genetics and EUROGOUT-Inflammation

Prediagnostic proteomics of gout: prospective cohort study of 48,898 men and women

Natalie McCormick, Amit Joshi, Robert Terkeltaub, Tony R. Merriman, Chio Yokose, Hyon K. Choi

3

2015 - Oral communication

OA-Genetics and EUROGOUT-Inflammation

Soluble urate primes inflammatory responses via activation of the Akt-PRAS40-mTOR pathway.

Tania O. Crișan (1), Maartje C.P. Cleophas (1), Kathrin Buffen (1), Tim L. Jansen (2), Charles Dinarello (1,3), Mihai G. Netea (1), Leo A.B. Joosten (1)

4

2015 - Oral communication

OA-Genetics and EUROGOUT-Inflammation

Inhibition of class I histone deacetylases as novel therapeutic option in gouty arthritis.

Maartje C.P. Cleophas (1), Tania O. Crişan (1), Charles A. Dinarello (1, 2), Mihai G. Netea (1), Leo A.B. Joosten (1)

5

2021 - Oral communication

OA-Genetics and EUROGOUT-Inflammation

Does excess weight affect gout risk differently among genetically predisposed individuals? Sex-specific prospective cohort findings over >26 years

Chio Yokose (1,2); Natalie Mccormick (1,2,3); Na Lu, (3,4); Amit D. Joshi, Mbbs (5); Hyon K. Choi (1,2,3,4)

6

2015 - Oral communication

OA-Genetics and EUROGOUT-Inflammation

Four different types of calcium pyrophosphate crystals differentially induced IL-1β production by THP-1 cells.

Laure Campillo-Gimenez (1), Pierre Gras (2), Christèle Combes (2), Martine Cohen-Solal (1,3), Frédéric Lioté (1,3), Hang-Korng Ea (1,3).

8

2024 - Oral communication

OA-Genetics and EUROGOUT-Inflammation

Transcriptomic analysis reveals a proinflammatory signature in Gout and Hyperuricemia

Valentin Nica (1), Medeea Badii (1,2),,Georgiana Cabău (1), Orsolya Gaal (1,2), Andreea-Manuela Mirea (1), Ioana Hotea (3, HINT Consortium, Cristina Pamfil (3), Simona Rednic (3), Radu A. Popp1,Yang Li (2,4), Tania O. Crișan (1,2), Leo A.B. Joosten (1,2)

9

2024 - Oral communication

OA-Genetics and EUROGOUT-Inflammation

Runt-related Transcription Factor (RUNX) 1 activation by Monosodium Urate Crystals influences the production of inflammatory cytokines in human monocytes.

Laura M. Merlo Pich (1), Viola Klück (1), Liesbeth van Emst(1), Ruiqi Liu(1), Martin Jaeger (1), Tania Crisan (2), Mihai G. Netea (1,3), Yang Li (1,4), Leo A.B. Joosten (1,2)

10

2021 - Oral communication

OA-Genetics and EUROGOUT-Inflammation

Translating the multi-trait regulatory landscape at SLC2A9

Megan Leask, James Boocock, Hyon Choi, Tayaza Fadason, Justin O’Sullivan, Lisa Stamp, Nicola Dalbeth, Julia Horsfield, Tony R Merriman

11

2020 - Oral communication

OA-Genetics and EUROGOUT-Inflammation

A putative role of IGF-1R in the pathogenesis of gout through transcription factor

R. Liu (1), O. Gaal (3), V. Klück (1), T. O. Crișan (3), S. Fanucchi (4), M. Mhlanga (4), L. Joosten (1, 2,3)

12

2021 - Oral communication

OA-Genetics and EUROGOUT-Inflammation

Recent findings in clinico-genetics analyses for clinically-defined gout

Hirotaka Matsuo (1), Masahiro Nakatochi (2), Akiyoshi Nakayama (1), Yusuke Kawamura (1), Yu Toyoda (1), Seiko Shimizu (1), Tappei Takada (3), Kimiyoshi Ichida (4), Nariyoshi Shinomiya (1), Yukinori Okada (5)

13

2023 - Oral communication

OA-Genetics and EUROGOUT-Inflammation

Sex and ethnicity-stratified analyses of gout comorbidities and gout genetic risk in the uk biobank and all of us cohorts

Nicholas A Sumpter, Murray J Cadzow, Riku Takei, Megan P Leask, Angelo Gaffo, Alexander So, Richard J Reynolds, Tony R Merriman

14

2021 - Oral communication

OA-Genetics and EUROGOUT-Inflammation

CD11B deficiency promotes inflammasome activation in macrophages and aggravates MSU-induced joint inflammation in mice

Driss Ehirchiou, Ilaria Bernabei, Veronique Chobaz, Sonia Nasi, Mariela Castelblanco , Alexander So , Hans Acha-Orbea, Thomas Hugle, Li Zhang, Nathalie Busso

15

2018 - Oral communication

OA-Genetics and EUROGOUT-Inflammation

Exon sequencing of SLC22A11 (OAT4) and SLC22A12 (URAT1) in hyperuricaemic individuals; genetic evidence of a role for OAT4 in urate secretion

Tanya J Major (1), James Boocock (1), Asim Mandal (6), Murray Cadzow (1), Ruth K Topless (1), Amanda J Phipps-Green (1), Nicola Dalbeth (2), Lisa K Stamp (3), David B Mount (4), Hyon K Choi (5), Eli A Stahl (6), Tony R Merriman (1)

Posters

16

2020 - Poster

OA-Genetics and EUROGOUT-Inflammation

Serum concentrations of IL-1β and IL-18 in gout patients out of flare are not connected to cardiovascular alterations

R. Gancheva (1), T. Velikova (2), T. Kundurzhiev (3), Z. Kolarov (1), A. Koundurdjiev (4)

17

2017 - Poster

OA-Genetics and EUROGOUT-Inflammation

Gout at the spine : a retrospective study with dual-energy computed tomography

E. Chotard (1), J. M. Sverzut (2) , F. Lioté (1,3), T. Bardin (1,3), H.K. Ea (1,3)

19

2017 - Poster

OA-Genetics and EUROGOUT-Inflammation

Circulating cytokines and homeostatic molecules are correlated to serum uric acid levels in gout and metabolic syndrome patients

Tania O. Crișan (1,2), Maartje C.P. Cleophas (1), Rob ter Horst (1), Inge van de Munckhof (1), Joost Rutten (1), Tim L. Jansen (3), Niels Riksen (1), Charles Dinarello (1,4), Mihai G. Netea (1), Leo A.B. Joosten (1,2)

20

2019 - Poster

OA-Genetics and EUROGOUT-Inflammation

Alpha-1-antitrypsin in relation to serum urate and inflammatory markers in patients; comparison between gout, asymptomatic hyperuricaemia and healthy controls.

I. Hotea (1), T. O. Crisan (2), C. Pamfil (1), M. Badii (2), O. Gall (2), L. Peca (2), A. Mirea (2), R. Popp (2), S. Rednic (1,3), L. Ab Joosten (2,4).